Models of Acquired Immunity to Malaria: A Review

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(a) Infants

(b) older people

Figure 5.5: Schematic illustration of malaria premunition reproduced from [165].

intra-host models of malaria [112] is that with time, NAI moves from variant-specific to

variant-transcending, as accumulated diversity of exposure increases.

In the same vein, a stochastic model of within-host immunity was employed to ex-

plore which form of immunity could account for the observed rates of reinfection in adults

and children in field data [6]. The model focused on the immunity impacting the growth

of blood-stage parasite, where such immunity might either be variant-specific (resulting